Prague, 1969. Dans un café, la patronne acariâtre et jalouse épie sa jeune serveuse. Elle assiste en voyeuse à l'éclosion et au massacre d'un amour pur, qui lui rappelle une blessure de jeunesse. A travers ce huis-clos et une poignée de personnages, c'est tout le cauchemar d'un régime politique qui nous est restitué.
Albert et Gina sont céramistes à Vallauris, mais Albert, depuis qu'il a subi une opération qui l'a défiguré, part souvent pour de longs voyages vers l'Orient. A la veille d'un périple en Méditerranée, il demande à Picasso, auquel il a dispensé autrefois des cours de poterie, de lui peindre un drapeau... Ce récit est raconté par la petite cousine d'Albert, adolescente invitée, chaque été, à venir passer quelques jours de vacances chez eux. Elle pressent très vite, devant ce couple qui se délite, l'influence inquiétante, presque maléfique, d'un être invisible... Visage halluciné peint sur le drapeau ? Comme une troisième personne qui s'amuse à le détruire -à détruire Gina surtout ? Ou tout simplement reflet - ou transfiguration - du visage étrange, et pour Gina devenu étranger, de celui qui vit à ses côtés...
L'enchevêtrement des corps nus n'eut pas le temps de se désunir. Ce fut un carnage très bref, ponctué de hurlements étouffés, de gargouillements grotesques, de bruits de chairs crevées, de succions gloutonnes, de giclées de sang noirâtre.
Pitt Ford's Problem-Based Learning in Endodontology combines the theory and practice of endodontics, providing the reader with information that is both clinically relevant to everyday practice and also evidence based. It includes a wealth of cases that span topics such as the maintenance of a vital pulp, root canal treatment, surgical endodontics and trauma. Each case is accompanied by full colour photographs and/or radiographs that illustrate the key stages in diagnosis, treatment planning, treatment and prognosis. In addition, the detailed commentary provides information on viable alternative treatment strategies, rationale (biologic considerations) for the treatment described, evaluation of the current evidence for/against the course of treatment and finally the prognosis. The book allows the reader to apply their existing knowledge to a range of clinical scenarios and to gain new knowledge and apply it to further clinical situations. In addition the reader will be encouraged to transfer knowledge and diagnostic skills from one problem to another and guided to improve their self-directed learning and reflective skills.
A revised and updated edition of the leading introductory text on the geography of economic life, from the local to the global Economic Geography is an engaging and accessible introduction to the different ways modern economic geographers understand, analyze, and interpret economic processes. This comprehensive text addresses significant questions relevant to contemporary economic life, from the activities of transnational corporations to issues surrounding workplaces and consumption. It encourages readers to explore how spatial patterns, places, networks, and territories shape large-scale economic processes. Accessible, highly-illustrated material presents fresh insights from the field-complemented by relatable, real-world examples that help students understand the social, cultural, and political contexts underpinning global economic processes. Now in its third edition, this extensively revised and updated textbook retains the features and thematic structure that have proved popular with students and instructors alike, while adding exciting new content. New chapters explore how the global economy and global development are institutionalized and governed, the economic geographies of global climate change, economic practices outside the capitalist mainstream, the role of migrants in labour markets, global production networks, and more. Introduces economic geography with a thematic approach including major concepts, current debates, and case studies Revised and updated to enhance international coverage, including three entirely new chapters on international development, alternative economies, and global climate change Substantial new content on labour migration, global production networks, and recent intellectual trends such as evolutionary economic geography Highly illustrated with diagrams and photographs closely integrated into the text Pedagogical aids including key case studies, learning objectives, text boxes, chapter essay questions, summaries, and further reading Core geographical concepts - such as place, networks and territory - are closely integrated into all chapters. Economic Geography: A Contemporary Introduction is an invaluable source of up-to-date knowledge for students new to the field, for those requiring a solid foundation, as well as for a broader academic and public readership with interest in this area of study.
This richly illustrated book combines explanation of the scientific base underpinning vital pulp treatment with description of current and emerging trends in clinical practice. It guides the reader through modern views on pulp diagnostics, deep caries, and pulp exposure management, leading to an analysis of the biological aspects of regenerative techniques such as angiogenesis, neurogenesis, inflammation, and epigenetics. In the later chapters, practical considerations relating to bioengineering, biomaterial choice, revitalization, and stem cell-based procedures are discussed and their likely therapeutic impact considered. Aimed at dental students, postgraduates, and research-minded dental practitioners, this translational book summarizes state-of-the-art scientific knowledge on dentin-pulp interactions and regenerative endodontics, while highlighting the opportunities to incorporate recent developments into everyday practice. Readers will also find extensive discussion of potential future developments and research avenues relating to each aspect of this exciting and rapidly developing field.
A top priority in climate research is obtaining broad-extent and long-term data to support analyses of historical patterns and trends, and for model development and evaluation. Along with directly measured climate data from the present and recent past, it is important to obtain estimates of long past climate variations spanning multiple centuries and millennia. These longer time perspectives are needed for assessing the unusualness of recent climate changes, as well as for providing insight on the range, variation and overall dynamics of the climate system over time spans exceeding available records from instruments, such as rain gauges and thermometers. Tree rings have become increasingly valuable in providing this long-term information because extensive data networks have been developed in temperate and boreal zones of the Earth, and quantitative methods for analyzing these data have advanced. Tree rings are among the most useful paleoclimate information sources available because they provide a high degree of chronological accuracy, high replication, and extensive spatial coverage spanning recent centuries. With the expansion and extension of tree-ring data and analytical capacity new climatic insights from tree rings are being used in a variety of applications, including for interpretation of past changes in ecosystems and human societies. This volume presents an overview of the current state of dendroclimatology, its contributions over the last 30 years, and its future potential. The material included is useful not only to those who generate tree-ring records of past climate-dendroclimatologists, but also to users of their results-climatologists, hydrologists, ecologists and archeologists. `With the pressing climatic questions of the 21st century demanding a deeper understanding of the climate system and our impact upon it, this thoughtful volume comes at critical moment. It will be of fundamental importance in not
only guiding researchers, but in educating scientists and the interested lay person on the both incredible power and potential pitfalls of reconstructing climate using tree-ring analysis.', Glen M. MacDonald, UCLA Institute of the Environment, CA, USA `This is an up-to-date treatment of all branches of tree-ring science, by the world's experts in the field, reminding us that tree rings are the most important source of proxy data on climate change. Should be read by all budding dendrochronology scientists.', Alan Robock, Rutgers University, NJ, USA
This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include:Solution, suspension, gel, nanoparticle, microparticle, and implant dosage formsRefillable and microneedle devicesIntravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of deliveryPhysical methods including iontophoresis for drug deliveryRational selection of routes of administration and delivery systemsNoninvasive and continuous drug monitoring Regulatory path to drug product developmentClinical endpoints for drug product developmentEmerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devicesIntravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of deliveryPhysical methods including iontophoresis for drug deliveryRational selection of routes of administration and delivery systemsNoninvasive and continuous drug monitoring Regulatory path to drug product developmentClinical endpoints for drug product developmentEmerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devicesIntravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of deliveryPhysical methods including iontophoresis for drug deliveryRational selection of routes of administration and delivery systemsNoninvasive and continuous drug monitoring Regulatory path to drug product developmentClinical endpoints for drug product developmentEmerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.
